GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs60843830 | 1 | rs58461606 | chr2:267367 | SH3YL1 | chr2:218138-264810:- | -0.95 | -26.36 | 3.27E-95 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs6911965 | 1 | rs58479700 | chr6:24483199 | GPLD1 | chr6:24428405-24489850:- | 0.2 | 3.75 | 0.0002 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs58479700 | chr6:24483199 | MRS2 | chr6:24403153-24425809:+ | 0.24 | 5.35 | 1.35E-7 | Hematological and biochemical traits |
| THCA | cis | rs4888671 | 1 | rs58484838 | chr16:77783137 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.95 | 1.04E-6 | Obesity-related traits |
| THCA | cis | rs17122021 | 1 | rs58507982 | chr11:118146510 | AMICA1 | chr11:118064442-118095809:- | 0.08 | 4.01 | 7.05E-5 | Pain |
| THCA | cis | rs17122021 | 1 | rs58507982 | chr11:118146510 | MPZL2 | chr11:118124135-118135009:- | 0.23 | 7.86 | 2.62E-14 | Pain |
| THCA | cis | rs17122021 | 1 | rs58507982 | chr11:118146510 | TREH | chr11:118528942-118550381:- | -0.17 | -3.39 | 0.000746 | Pain |
| THCA | cis | rs35123781 | 1 | rs585101 | chr5:139058454 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.5 | 0.000508 | Schizophrenia |
| THCA | cis | rs4905558 | 1 | rs58514314 | chr14:97338825 | VRK1 | chr14:97263684-97347950:+ | -0.17 | -3.86 | 0.00013 | Neutrophil count |
| THCA | cis | rs2241437 | 1 | rs58515922 | chr2:86173037 | POLR1A | chr2:86253453-86333278:- | -0.23 | -3.64 | 0.000302 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs7116495 | 1 | rs585228 | chr11:71773289 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs17401966 | 1 | rs58549151 | chr1:10314657 | KIF1B | chr1:10270764-10441659:+ | 0.21 | 6.36 | 4.75E-10 | Hepatocellular carcinoma |
| THCA | cis | rs7216064 | 1 | rs58551145 | chr17:65837235 | C17orf58 | chr17:65987218-65989765:- | 0.2 | 3.89 | 0.000114 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs7107174 | 1 | rs58565853 | chr11:78036707 | NARS2 | chr11:78147017-78285909:- | -0.37 | -6.82 | 2.72E-11 | Testicular germ cell tumor |
| THCA | cis | rs2111504 | 1 | rs58591218 | chr19:32890782 | DPY19L3 | chr19:32896677-32975236:+ | 0.2 | 5.29 | 1.82E-7 | Bipolar disorder |